GW 841819X ( GW841819X )

Catalog No. M11985 CAS No. 146135-18-4

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Product Name

GW 841819X
Note

Research use only, not for human use.
Brief Description

GW 841819X is an analogue of (+)-JQ1 and a novel inhibitor of BET bromodomain.
Description

GW 841819X is an analogue of (+)-JQ1 and a novel inhibitor of BET bromodomain that displays activity in vivo against NUT-midline carcinoma, multiple myeloma, mixed-lineage leukemia, and acute myeloid leukemia.
Synonyms

GW841819X
Pathway

Chromatin/Epigenetic
Target

Bromodomain
Recptor

Bromodomain
Research Area

——
Indication

——

CAS Number

146135-18-4
Formula Weight

487.94
Molecular Formula

C26H22ClN5O3
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(OCC1=CC=CC=C1)N[C@H]2C3=NN=C(C)N3C4=CC=C(OC)C=C4C(C5=CC=C(Cl)C=C5)=N2
Chemical Name

(R)-benzyl (6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)carbamate

1. Chung CW, et al. J Med Chem. 2011 Jun 9;54(11):3827-38.
2. Baud MG, et al. Science. 2014 Oct 31;346(6209):638-41.

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